Abbott Point of Care (APOC) partners with physicians and researchers globally to advance scientific knowledge and evidence of our products in various clinical settings to help accelerate patient care. Below is a compilation of peer reviewed journal articles and editorials demonstrating the clinical, analytical, operational, and economic value of APOC products.
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| Title | SOurce | Sample size | Summary |
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Implementation of Point of Care Testing in the Emergency Department of a Teaching Hospital in U.A.E |
JOURNAL OF CLINICAL CHEMISTRY AND LABORATORY MEDICINE, Howayyer et al 2019; 2:123 |
50 (method comparison) |
Objectives: Analytical performance of i-STAT Alinity testing system was evaluated against laboratory methods in the Emergency Department (ED) of a tertiary care hospital. i-STAT CG4+ and CHEM8+ cartridges were used. User satisfaction was evaluated through a post operator training survey by non-laboratory personnel. Findings: i-STAT Alinity demonstrated good correlation with standard laboratory methods along with satisfactory precision and linearity for all analytes tested. Analytical ranges for all the tested analytes were within the reportable range except creatinine which was slightly higher. The user friendly features of i-STAT Alinity, portability of the instrument and rapid results led to high operator confidence and a positive impact on patient treatment and disposition. |
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THE JOURNAL OF EMERGENCY MEDICINE, |
104 (52 patients and 52 matched controls) |
Objectives: Value of early point of care testing (POCT) at the time of patient triage prior to physician evaluation in the Emergency Department (ED) was evaluated at a tertiary care medical center. POCT was available for basic metabolic panel, troponin I, lactate, International Normalized Ratio (INR), or urine pregnancy test. Findings: ED care times reduced by approximately 1 hour with early POCT at triage compared with traditional core laboratory testing. Approximately 6% of the patients were immediately transferred to critical care areas to be seen by an ED physician. Slightly more than half of the treating physicians felt that early POCT at the time of initial assessment improved patient care, by changing the focus of their evaluation or leading to earlier treatment or disposition. In this study, although ED care times were reduced, total ED length of stay was not reduced. |
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Does Rapid Assessment Shorten the Amount of Time Patients Spend in the Emergency Department? |
BRITISH JOURNAL OF HOSPITAL MEDICINE, *Dr. Jarvis no longer works as a consultant at Calderdale Royal Hospital and he is currently employed by Abbott Laboratories. |
4,622 |
Objectives: Traditional patient triage (nurse-led triage model with blood samples analyzed in a centralized hospital laboratory) was compared with a consultant-supported rapid assessment model (EDIT model) with blood samples analyzed using the i-STAT System as the point of care (POC) solution in the Emergency Department (ED) of a district general hospital. |
| Time is Money— The Economic Impact of Point of Care on the Emergency Department of a Tertiary Care University Hospital | POINT OF CARE, Schilling 2014; 13:21-23 |
41 | Objectives: Economic value of point of care testing (POCT) was assessed in a Swedish Emergency Department. Direct cost of POCT vs. central laboratory and indirect costs such as reduction in waiting time was analyzed. i-STAT CHEM8+, CG4+, and cTnI cartridges were used. Findings: For similar tests, there was a direct cost saving of US $111/patient with POCT as compared to central laboratory. Indirect cost savings were US $72.75/patient, including staffing costs and time saving. These findings might not reflect the findings in other clinical settings. Numbers should be recalculated in the actual local setting to reveal if the direct savings of POCT testing can be realized at the respective hospital. |
| ADVANCED EMERGENCY NURSING JOURNAL, Koehler et al 2013; 35:270-277 |
201 |
Objectives: Impact of point of care (POC) troponin testing on turnaround times, door-to-troponin result time, ED Length of Stay (LOS) in patients with chest pain, and staff satisfaction with POC testing was evaluated. |
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| Title | SOurce | sample size | Summary |
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Clinical Evaluation of Measuring the ACT During Elective Cardiac Surgery with Two Different Devices |
JOURNAL OF EXTRA CORPOREAL TECHNOLOGY, |
402 |
Objectives: Multi-site study across UK, South Africa and Switzerland evaluated Activated Clotting Time (ACT) measurements with two devices, i-STAT and Hemochron Jr. Patients undergoing elective cardiac surgery on cardiopulmonary bypass were included. Findings: i-STAT ACT test demonstrated good correlation with Hemochron Jr with i-STAT reading slightly higher than Hemochron Jr. Additionally, i-STAT consistently demonstrated lower within-subject coefficient of variation (WSCV) compared to Hemochron Jr, making it more reliable for clinical decision making. Authors commented that the better reliability of the i-STAT may be due to the difference in ACT methodology. |
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A Two Site Comparison of Two Point of Care Activated Clotting Time Systems |
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, Kemna EW et al 2017; 55:e13-e16 |
177 |
Objectives: i-STAT Activated Clotting Time (ACT) and Hemochron Signature Elite ACT values were compared using split samples from patients undergoing invasive surgery at two cardiothoracic institutes in the Netherlands and Germany. Findings: i-STAT ACT values demonstrated better reproducibility (mean difference - 4.3% vs. 9.1%) and correlation compared to the Hemochron. In the therapeutic area (>250 s), Hemochron duplicate measurements became less precise. There are different possible explanations for the correlation results between the Hemochron and the i-STAT. The i-STAT is less susceptible to changes in fibrinogen levels, temperature, hematocrit and hemodilution compared to the Hemochron. These findings reflects precision and not accuracy. Since there is no true ACT value, clinicians rely on the precision (reproducibility) of tests. |
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| Title | SOurce | sample size | Summary |
| CLINICO ECONOMICS AND OUTCOME RESEARCH, Spaeth et al 2018; 29:269-277 |
200 |
Objectives: Economic value of i-STAT point-of-care (POCT) testing at six primary health care facilities in rural and remote communities in Australia, where hospital and laboratory facilities are unavailable were evaluated. Economic evaluation was conducted using data from patients presenting with three common acute conditions (chest pain, chronic renal failure due to missed dialysis session(s), and acute diarrhea). The number of unnecessary medical evacuations prevented with the use of POCT as an aid in decision-making for acutely ill patients was used as a basis of calculating cost savings per patient and Northern Territory (NT) wide. |
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