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An updated, evidence-based bundle from the Surviving Sepsis Campaign (SSC), released in 2018, emphasizes expediency of care to improve survival.
2018 SSC Hour-1 Bundle: |
Measure lactate level. Re-measure if initial lactate is >2 mmol/L |
Obtain blood cultures prior to administration of antibiotics |
Administer broad-spectrum antibiotics |
Rapidly administer 30 ml/kg crystalloid for hypotension or lactate ≥4 mmol/L |
Apply vasopressors if patient is hypotensive during or after fluid resuscitation to maintain MAP ≥65 mm Hg |
1. CDC Sepsis Fact Sheet.
2. Hand Hygiene Day its in your hands prevent sepsis in health care, WHO Europe Website. www.euro.who.int/en/health-topics
3. Advisory Board Sepsis Research Report.
4. Levy MM, Evans LE, Rhodes A.
5. Singer AJ, Taylor M, LeBlanc D et al. 2014.
6. Singer AJ, Taylor M, LeBlanc D et al. 2018.
7. Ward MJ, Self WH, Singer A et al.
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