Sepsis: Transform
Risk Stratification
at the bedside

A deadly and costly crisis


~1 in 3 patients who die in the hospital have sepsis1


#1 inpatient cost in US hospitals, totaling >$27 billion/year2


Leading cause of US in-hospital mortality, up to 70% in patients with septic shock3,4

Sepsis mortality — one hour makes all the difference

An updated, evidence-based bundle from the Surviving Sepsis Campaign (SSC), released in 2018, emphasizes expediency of care to improve survival.

2018 SSC Hour-1 Bundle:
Measure lactate level. Re-measure if initial lactate is >2 mmol/L 
Obtain blood cultures prior to administration of antibiotics 
Administer broad-spectrum antibiotics 
Rapidly administer 30 ml/kg crystalloid for hypotension or lactate ≥4 mmol/L 
Apply vasopressors if patient is hypotensive during or after fluid resuscitation to maintain MAP ≥65 mm Hg 
  • Lactate-guided resuscitation is associated with significantly reduced mortality5
  • Yet only 53% of clinicians order lactate with blood culture for patients with sepsis4
  • When lactate is ordered, long turnaround times have been identified as a barrier to bundle compliance4


Every hour sepsis treatment is delayed once the patient has developed hypotension, risk of death increases by up
to 8%9

i-STAT CG4+ — Expediting Risk Stratification to optimize acuity-based care

When every minute counts, i-STAT CG4+ improves care team efficiency, coordination, and communication─quickly guiding resources to those who need it most.

In clinical studies, i-STAT CG4+ has been shown to significantly improve ED efficiency and quality.

  • Reduced door-to-lactate result time by 72%6
  • Reduced ED care time (arrival-to-disposition decision) by 11%7 
  • Provided a cost-effective means to identify patients benefitting from early resuscitation8
Want more information about how your organization
can achieve sepsis care transformation?

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1. CDC Sepsis Fact Sheet.
2. What is Sepsis? Infographic.  Sepsis Alliance.
3. Sepsis Alliance Sepsis Fact Sheet. 
4. Advisory Board Sepsis Research Report.
5. Levy MM, Evans LE, Rhodes A.
6. Singer AJ, Taylor M, LeBlanc D et al. 2014.
7. Singer AJ, Taylor M, LeBlanc D et al. 2018.
8. Ward MJ, Self WH, Singer A et al.
9. Kumar et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. June 2006.

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