An updated, evidence-based bundle from the Surviving Sepsis Campaign (SSC), released in 2018, emphasizes expediency of care to improve survival.
|2018 SSC Hour-1 Bundle:|
|Measure lactate level. Re-measure if initial lactate is >2 mmol/L|
|Obtain blood cultures prior to administration of antibiotics|
|Administer broad-spectrum antibiotics|
|Rapidly administer 30 ml/kg crystalloid for hypotension or lactate ≥4 mmol/L|
|Apply vasopressors if patient is hypotensive during or after fluid resuscitation to maintain MAP ≥65 mm Hg|
1. CDC Sepsis Fact Sheet.
2. What is Sepsis? Infographic. Sepsis Alliance. www.sepsis.org
3. Sepsis Alliance Sepsis Fact Sheet.
4. Advisory Board Sepsis Research Report.
5. Levy MM, Evans LE, Rhodes A.
6. Singer AJ, Taylor M, LeBlanc D et al. 2014.
7. Singer AJ, Taylor M, LeBlanc D et al. 2018.
8. Ward MJ, Self WH, Singer A et al.
9. Kumar et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. June 2006. https://www.ncbi.nlm.nih.gov/pubmed/16625125
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